![]() ![]() A highly stable short alpha-helix constrained by a main-chain hydrogen-bond surrogate. ![]() Facile and E-selective intramolecular ring-closing metathesis reactions in 3(10)-helical peptides: a 3D structural study. Use of onium salt-based coupling reagents in peptide synthesis. 1-hydroxy-7-azabenzotriazole-an efficient peptide coupling additive. P圜locK, the phosphonium salt derived from 6-Cl- HOBt. Fast conventional Fmoc solid-phase peptide synthesis with HCTU. Assessment of new 6-Cl-HOBt based coupling reagents for peptide synthesis. New coupling reagents: development and industrial aspects. in Programmed Cell Death, The Biology and Therapeutic Implications of Cell Death, Part B. Synthesis and biophysical characterization of stabilized alpha-helices of BCL-2 domains. Convenient, large-scale asymmetric synthesis of enantiomerically pure trans-cinnamylglycine and -alpha-alanine. Qiu, W., Soloshonok, V.A., Cai, C.Z., Tang, X.J. Improved procedures for the synthesis of ( S)-2-benzophenone (BPB) and Ni(II) complexes of Schiff's bases derived from BPB and amino acids. Asymmetric-synthesis of monosubstituted and alpha,alpha-disubstituted alpha-amino-acids via diastereoselective glycine enolate alkylations. Stereochemical effects of all-hydrocarbon tethers in i, i+4 stapled peptides. Introduction of all-hydrocarbon i, i+3 staples into alpha-helices via ring-closing olefin metathesis. A stapled p53 helix overcomes HDMX-mediated suppression of p53. A stapled BID BH3 helix directly binds and activates BAX. Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic. The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer. ![]() Direct inhibition of the NOTCH transcription factor complex. BAX activation is initiated at a novel interaction site. Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide. A cell-penetrating helical peptide as a potential HIV-1 inhibitor. Solution structure of a hydrocarbon stapled peptide inhibitor in complex with monomeric C-terminal domain of HIV-1 capsid. Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix. Highly efficient synthesis of covalently crosslinked peptide helices by ring-closing metathesis. An all-hydrocarbon cross-linking system for enhancing the helicity and metabolic stability of peptides. Contemporary strategies for the stabilization of peptides in the alpha-helical conformation. Toward the design of highly efficient, readily accessible peptide N-caps for the induction of helical conformations. The challenge of drugging undruggable targets in cancer: lessons learned from targeting BCL-2 family members. However, top sheets are available and sold separately.Verdine, G.L. It’s also worth noting the Parachute has hopped onto the trend of ditching the top sheet, so this set only comes with a fitted sheet and pillowcases. ![]() While buyers can choose from eight sheet colors, including the usual suspects (white and light gray), Parachute has just introduced some new and unexpected color options, including Raisin and Moss. These sheets are available in six sizes ranging from twin to California king. It’s worth noting that Parachute’s percale sheets are garment washed, so while they may have a crisp hand, they’re still soft and smooth. Made of long-staple Egyptian cotton and constructed with a matte, one-over-one-under weave, these percale sheets may not have the silky feel their sateen counterparts do, but they’re light, crisp and breathable. If cotton cooling sheets are on your radar, you might want to take a closer look at Parachute’s Percale Sheet Set. ![]()
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